Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells.

@article{Nakazato2007MyeloperoxidaseIA,
  title={Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells.},
  author={Tomonori Nakazato and M Sagawa and Kenji Yamato and Mingji Xian and Takehiro Yamamoto and Makoto Suematsu and Yasuo Ikeda and Masahiro Kizaki},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 18 Pt 1},
  pages={5436-45}
}
PURPOSE We reported previously that reactive oxygen species (ROS) are key mediators of apoptosis induced by a polyphenol, (-)-epigallocatechin-3-gallate (EGCG), in myeloid leukemic cells. This study aimed to further examine the mechanism of ROS-mediated apoptosis induced by EGCG and its relationship to the heme enzyme myeloperoxidase (MPO). EXPERIMENTAL DESIGN We established stably transfected K562 cells expressing wild-type and mutant MPO. Then, sensitivity against EGCG and other ROS… CONTINUE READING

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