Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.

  title={Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.},
  author={Robert A. Clark and Phillip J. Stone and A I el Hag and James D. Calore and Carl Franzblau},
  journal={The Journal of biological chemistry},
  volume={256 7},
We have examined the effect of the myeloperoxidase-hydrogen peroxide-halide system and of activated human neutrophils on the ability of serum alpha 1-protease inhibitor (alpha 1-PI) to bind and inhibit porcine pancreatic elastase. Exposure to the isolated myeloperoxidase system resulted in nearly complete inactivation of alpha 1-PI. Inactivation was rapid (10 to 20 s); required active myeloperoxidase, micromolar concentrations of H2O2 (or glucose oxidase as a peroxide generator), and a halide… CONTINUE READING


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