Myeloperoxidase as a generator of drug free radicals.

  title={Myeloperoxidase as a generator of drug free radicals.},
  author={J. Uetrecht},
  journal={Biochemical Society symposium},
  • J. Uetrecht
  • Published 1995
  • Chemistry, Medicine
  • Biochemical Society symposium
  • Reactive metabolites are believed to be responsible for many types of toxicity, including idiosyncratic drug reactions. Bone marrow is a frequent target of idiosyncratic reactions, and, since these reactions have characteristics that suggest involvement of the immune system, the formation of reactive metabolites by leucocytes could also play a role in the aetiology of idiosyncratic drug reactions. The major oxidation system in neutrophils and monocytes is a combination of NADPH oxidase and… CONTINUE READING
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