Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation

@article{Rudolph2010MyeloperoxidaseAA,
  title={Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation},
  author={Volker med. Rudolph and Ren{\'e} P Andri{\'e} and Tanja Katharina Rudolph and Kai Peter Friedrichs and Anna Klinke and Birgit Hirsch-Hoffmann and Alexander Peter Schwoerer and Denise Lau and Xiaoming Fu and Karin Klingel and Karsten Sydow and Michael Didi{\'e} and Alicja Seniuk and Eike-Christin von Leitner and Katalin Szoecs and Jan Wilko Schrickel and Hendrik Treede and Ulrich Wenzel and Thorsten Lewalter and Gerog Nickenig and Wolfram H Zimmermann and Thomas Meinertz and Rainer H. Boeger and Hermann C. Reichenspurner and Bruce A. Freeman and Thomas Eschenhagen and Heimo Ehmke and Stanley L. Hazen and Stephan Willems and Stephan Baldus},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={470-474}
}
Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation. However, whether inflammation is the cause or the consequence of atrial fibrillation and which specific inflammatory mediators may increase the atria's susceptibility to fibrillation remain elusive. Here we provide experimental and clinical evidence for the mechanistic involvement of myeloperoxidase (MPO), a heme enzyme abundantly expressed by neutrophils, in the… CONTINUE READING
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