Myeloperoxidase: friend and foe.

  title={Myeloperoxidase: friend and foe.},
  author={Seymour J. Klebanoff},
  journal={Journal of leukocyte biology},
  volume={77 5},
Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their primary function, the phagocytosis and destruction of microorganisms. When coated with opsonins (generally complement and/or antibody), microorganisms bind to specific receptors on the surface of the phagocyte and invagination of the cell membrane occurs with the incorporation of the microorganism into an intracellular phagosome. There follows a burst of oxygen consumption, and much, if not all, of the… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 488 references

Verdoperoxidase. A ferment isolated from leucocytes

K. Agner
Acta Chem. Scand. A 2 (Suppl • 1941
View 4 Excerpts
Highly Influenced

The catalytic decomposition of hydrogen peroxide by iron salts

F. Haber, J. Weiss
Proc. R. Soc. Lond. A • 1934
View 6 Excerpts
Highly Influenced

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 3 Excerpts
Highly Influenced

Myeloperoxidase-mediated antimicrobial systems and their role in leukocyte function

S. J. Klebanoff
In Biochemistry of the Phagocytic Process (J • 1970
View 4 Excerpts
Highly Influenced

[pH changes of cytoplasm in phagocytosis of microbes stained with indicator dyes].

Biulleten' eksperimental'noi biologii i meditsiny • 1967
View 2 Excerpts
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