Myeloperoxidase: expression and modulation in a large panel of human leukemia-lymphoma cell lines.

  title={Myeloperoxidase: expression and modulation in a large panel of human leukemia-lymphoma cell lines.},
  author={Zhi Bi Hu and W Ma and Cord C. Uphoff and K Metge and Suzanne M. Gignac and H. G. Drexler},
  volume={82 5},
Myeloperoxidase (MPO) is found exclusively in the azurophilic granules (primary lysosomes) of normal myelomonocytic cells. Cytochemical staining for MPO activity is used clinically to distinguish myeloid from lymphoid leukemias. We studied the expression of MPO at the RNA and protein level in 140 continuous human leukemia-lymphoma cell lines using classical cytochemistry, immunofluorescent staining with a specific monoclonal antibody, Northern blot analysis, and a reverse transcription… CONTINUE READING
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