Myelomonocytic cells are sufficient for therapeutic cell fusion in liver

  title={Myelomonocytic cells are sufficient for therapeutic cell fusion in liver},
  author={Holger Willenbring and Alexis S Bailey and Mark Foster and Yassmine M N Akkari and Craig Dorrell and Susan Olson and Milton L Finegold and William Harv Fleming and Markus Grompe},
  journal={Nature Medicine},
Liver repopulation with bone marrow–derived hepatocytes (BMHs) can cure the genetic liver disease fumarylacetoacetate hydrolase (Fah) deficiency. BMHs emerge from fusion between donor bone marrow–derived cells and host hepatocytes. To use such in vivo cell fusion efficiently for therapy requires knowing the nature of the hematopoietic cells that fuse with hepatocytes. Here we show that the transplantation into Fah−/− mice of hematopoietic stem cells (HSCs) from lymphocyte-deficient Rag1−/− mice… CONTINUE READING