Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity.

@article{Yaccoby2002MyelomaIW,
  title={Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity.},
  author={Shmuel Yaccoby and Roger Niles Pearse and Cherie L Johnson and Bart Barlogie and Yongwon Choi and Joshua Epstein},
  journal={British journal of haematology},
  year={2002},
  volume={116 2},
  pages={278-90}
}
Myeloma tumour growth, except in the most advanced stages of the disease, is restricted to the bone marrow. We used the severe combined immunodeficient-human (SCID-hu) host system, in which primary human myeloma cells grow in, disseminate to and interact with a human microenvironment, to study the interactions between myeloma cells and cells in the bone marrow microenvironment. We used inhibitors of osteoclast activity to determine the role of osteoclasts and their products in supporting… CONTINUE READING

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