Myeloma cell-derived Runx2 promotes myeloma progression in bone.


The progression of multiple myeloma (MM) is governed by a network of molecular signals, the majority of which remain to be identified. Recent studies suggest that Runt-related transcription factor 2 (Runx2), a well-known bone-specific transcription factor, is also expressed in solid tumors, where expression promotes both bone metastasis and osteolysis… (More)
DOI: 10.1182/blood-2014-12-613968


8 Figures and Tables