Myeloma bone disease: recent advances in biology, diagnosis, and treatment.

  title={Myeloma bone disease: recent advances in biology, diagnosis, and treatment.},
  author={Orhan Sezer},
  journal={The oncologist},
  volume={14 3},
Bone disease is a hallmark of multiple myeloma (MM). Occurring in the majority of MM patients, it is associated with bone pain, fractures, and hypercalcemia and has major impacts on quality of life. Furthermore, bone resorption activity has been shown to be an independent risk factor for overall survival in patients with symptomatic MM. Myeloma is characterized by a unique form of bone disease with lytic bone destruction that is not followed by reactive bone formation (uncoupling). This review… CONTINUE READING


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