Myeloma as a model for the process of metastasis: implications for therapy.

@article{Ghobrial2012MyelomaAA,
  title={Myeloma as a model for the process of metastasis: implications for therapy.},
  author={Irene M Ghobrial},
  journal={Blood},
  year={2012},
  volume={120 1},
  pages={20-30}
}
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of multiple myelomatous "omas" throughout the skeleton, indicating that there is continuous trafficking of tumor cells to multiple areas in the bone marrow niches. MM may therefore represent one of the best models to study cell trafficking or cell metastasis. The process of cell metastasis is described as a multistep process, the invasion-metastasis cascade. This involves cell invasion, intravasation into nearby… CONTINUE READING
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