'Myelokathexis'. Neutropenia with marrow hyperplasia.

Abstract

A 10-year-old girl was first seen at age 5 years with pneumonia and neutropenia. Since then, she has remained leukopenic, although manifesting a leukocytosis only when she has pulmonary infection. A rapid fall in her peripheral WBC count occurs with initiation of antibiotic therapy. Despite her neutropenia, marked myeloid hyperplasia is evident on marrow smear examination; many cells being hypersegmented with fine intralobular bridging with chromatin strands and cytoplasmic vacuolation. The peripheral WBC response to epinephrine adminstration did not indicate a shift from the circulating to marginal neutrophil pool. Results from a Rebuck skin window test suggested poor neutrophil tissue migration. A defect in granulocyte release from the patient's marrow may explain these bizarre hematologic findings.

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@article{Oregan1977MyelokathexisNW, title={'Myelokathexis'. Neutropenia with marrow hyperplasia.}, author={Sean O'regan and Arthur J Newman and Richard Graham}, journal={American journal of diseases of children}, year={1977}, volume={131 6}, pages={655-8} }