Myeloid suppressor cells and immune modulation in lung cancer.

@article{Srivastava2012MyeloidSC,
  title={Myeloid suppressor cells and immune modulation in lung cancer.},
  author={Minu K. Srivastava and {\AA}sa Andersson and Li Zhu and Marni E. Harris-White and Jay Moon Lee and Steven Dubinett and Sherven P Sharma},
  journal={Immunotherapy},
  year={2012},
  volume={4 3},
  pages={291-304}
}
Many tumors, including lung cancers, promote immune tolerance to escape host immune surveillance and facilitate tumor growth. Tumors utilize numerous pathways to inhibit immune responses, including the elaboration of immune-suppressive mediators such as PGE2, TGF-β, IL-10, VEGF, GM-CSF, IL-6, S100A8/A9 and SCF, which recruit and/or activate myeloid-derived suppressor cells (MDSCs). MDSCs, a subset of heterogeneous bone marrow-derived hematopoietic cells, are found in the peripheral blood of… CONTINUE READING
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