Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet


High fat diet-induced obesity is associated with inflammatory and oxidative signaling in macrophages that likely participates in metabolic and physiologic impairment. One key factor that could drive pathologic changes in macrophages is the pro-inflammatory, pro-oxidant enzyme NADPH oxidase. However, NADPH oxidase is a pleiotropic enzyme with both pathologic… (More)
DOI: 10.1371/journal.pone.0181500


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