Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis.

@article{Lingrel2012MyeloidspecificKF,
  title={Myeloid-specific Kr{\"u}ppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis.},
  author={Jerry B. Lingrel and Robyn Pilcher-Roberts and Joshua E. Basford and Palanikumar Manoharan and Jon C. Neumann and Eddy S. Konaniah and Ramprasad Srinivasan and Vladimir Y. Bogdanov and David Y Hui},
  journal={Circulation research},
  year={2012},
  volume={110 10},
  pages={1294-302}
}
RATIONALE Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has been shown previously to augment atherosclerosis in hypercholesterolemic mice. However, the cell type responsible for the increased atherosclerosis due to KLF2 deficiency has not been identified. This study examined the consequence of myeloid cell-specific KLF2 inactivation in atherosclerosis. METHODS AND RESULTS Cell-specific knockout mice were generated by Cre/loxP recombination. Macrophages… CONTINUE READING
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