Myeloid expression of angiotensin converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells

@inproceedings{Shen2014MyeloidEO,
  title={Myeloid expression of angiotensin converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells},
  author={Xiao Z. Shen and Derick Okwan-Duodu and Wendell-Lamar B. Blackwell and Frank S. Ong and Tea Janjulia and Ellen A. Bernstein and S{\'e}bastien Fuchs and Serhan Alkan and K. E. Bernstein},
  booktitle={Laboratory Investigation},
  year={2014}
}
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells which accumulate in cancer, infection and chronic inflammation. These cells suppress T-cell function and the immune response. Angiotensin-converting enzyme (ACE) is a peptidase that is now known to regulate aspects of myelopoiesis. Here, we show that ACE… CONTINUE READING