Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia.

@article{Cai2009MyeloidDP,
  title={Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia.},
  author={Shanshan Cai and Rachel L Zemans and Scott K. Young and George Scott Worthen and Samithamby Jeyaseelan},
  journal={American journal of respiratory cell and molecular biology},
  year={2009},
  volume={40 6},
  pages={701-9}
}
Bacterial pneumonia remains a serious disease. Pattern recognition receptors play an integral role in neutrophil accumulation during pneumonia. Although myeloid differentiation protein (MD)-2 has been recognized as a key molecule for LPS signaling, the role of MD-2 in neutrophil accumulation in the lung during bacterial infection has not been explored. Here, we investigate the role of MD-2 in Escherichia coli LPS-induced lung inflammation and E. coli-induced pneumonia. LPS-induced CD14… CONTINUE READING

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