Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila.

@article{Hawn2006MyeloidDP,
  title={Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila.},
  author={Thomas Richard Hawn and Kelly D. Smith and Alan Aderem and Shawn J. Skerrett},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={193 12},
  pages={1693-702}
}
BACKGROUND Toll-like receptors (TLRs) are a family of proteins that orchestrate innate immune responses to microbes. Although pathogens are typically recognized by multiple TLRs, the specific roles of individual TLRs in mediating host protection during in vivo infection are not well understood. METHODS We compared the roles of myeloid differentiation primary response gene (88) (MyD88), which regulates signaling through multiple TLRs, and TLR2 in mediating resistance to aerosolized Legionella… CONTINUE READING

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