Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.

@article{Albiger2005MyeloidDF,
  title={Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.},
  author={Barbara Albiger and Andreas Sandgren and Hiroaki Katsuragi and Ulf Meyer-Hoffert and Katharina Beiter and Florian Wartha and Mathias Hornef and Staffan J. Normark and Birgitta Henriques Normark},
  journal={Cellular microbiology},
  year={2005},
  volume={7 11},
  pages={1603-15}
}
The Toll-like receptors (TLRs) and the myeloid differentiation factor 88 (MyD88) are key players in the activation of the innate immune defence during microbial infections. Using different murine infection models, we show that MyD88-dependent signalling is crucial for the activation of the innate immune defence against Streptococcus pneumoniae. Our data demonstrate that both local and systemic inflammatory response to S. pneumoniae depends on the presence of MyD88 to clear bacterial… CONTINUE READING

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