Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.

@article{Blyszczuk2009MyeloidDF,
  title={Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.},
  author={Przemyslaw Blyszczuk and Gabriela Kania and Thomas Dieterle and Ren{\'e} R. Marty and Alan Valaperti and Corinne Berthonneche and Thierry Pedrazzini and Christoph T Berger and Stephan R Dirnhofer and Christian M Matter and Josef M. Penninger and Thomas F L{\"u}scher and Urs Eriksson},
  journal={Circulation research},
  year={2009},
  volume={105 9},
  pages={912-20}
}
RATIONALE The myeloid differentiation factor (MyD)88/interleukin (IL)-1 axis activates self-antigen-presenting cells and promotes autoreactive CD4(+) T-cell expansion in experimental autoimmune myocarditis, a mouse model of inflammatory heart disease. OBJECTIVE The aim of this study was to determine the role of MyD88 and IL-1 in the progression of acute myocarditis to an end-stage heart failure. METHODS AND RESULTS Using alpha-myosin heavy chain peptide (MyHC-alpha)-loaded, activated… CONTINUE READING

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