Myeloid development is selectively disrupted in PU.1 null mice.

  title={Myeloid development is selectively disrupted in PU.1 null mice.},
  author={Karen L. Anderson and Kent A. Smith and Kris Conners and Scott R Mckercher and Richard A Maki and Bruce E. Torbett},
  volume={91 10},
The ets family transcription factor PU.1 is expressed in monocytes/macrophages, neutrophils, mast cells, B cells, and early erythroblasts, but not in T cells. We have recently shown that PU.1 gene disruption results in mice with no detectable monocytes/macrophages and B cells but T-cell development is retained. Although neutrophil development occurred in these mice, it was delayed and markedly reduced. We now proceed to demonstrate that PU. 1 null hematopoietic cells fail to proliferate or form… CONTINUE READING
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