Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-κB pathways.

@article{Lin2014MyeloidderivedTP,
  title={Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-κB pathways.},
  author={Ling Lin and Yang Jin and Wendy M. Mars and W. Brian Reeves and Kebin Hu},
  journal={The American journal of pathology},
  year={2014},
  volume={184 10},
  pages={2757-67}
}
Macrophage accumulation is one of the hallmarks of progressive kidney disease. Tissue-type plasminogen activator (tPA) is known to promote macrophage infiltration and renal inflammation during chronic kidney injury. However, the underlying mechanism remains largely unknown. We examined the role of tPA in macrophage motility in vivo by tracking fluorescence-labeled bone marrow-derived macrophages, and found that tPA-deficient mice had markedly fewer infiltrating fluorescence-labeled macrophages… CONTINUE READING