Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion.

@article{Leonard2016MyeloidderivedSC,
  title={Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion.},
  author={Wim Leonard and In{\`e}s Dufait and Julia Katharina Schwarze and Kalun Law and Benedikt Engels and Heng Jiang and Dirk L Van den Berge and Thierry Gevaert and Guy Storme and Valeri N. Verovski and Karine Breckpot and Mark de Ridder},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2016},
  volume={119 2},
  pages={
          291-9
        }
}
  • W. Leonard, I. Dufait, +9 authors M. de Ridder
  • Published 2016
  • Medicine
  • Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
BACKGROUND AND PURPOSE High arginase-1 (Arg) expression by myeloid-derived suppressor cells (MDSC) is known to inhibit antitumor T-cell responses through depletion of l-arginine. We have previously shown that nitric oxide (NO), an immune mediator produced from l-arginine, is a potent radiosensitizer of hypoxic tumor cells. This study therefore examines whether Arg(+) overexpressing MDSC may confer radioresistance through depleting the substrate for NO synthesis. MATERIAL AND METHODS MDSC and… Expand
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