Myeloid-derived suppressor cells modulate B-cell responses.

@article{Lelis2017MyeloidderivedSC,
  title={Myeloid-derived suppressor cells modulate B-cell responses.},
  author={Felipe Lelis and Jennifer Jaufmann and Anurag Singh and Katja Fromm and Annkathrin Chiara Teschner and Simone P{\"o}schel and Iris Schaefer and Sandra Beer-Hammer and Nikolaus Rieber and Dominik Hartl},
  journal={Immunology letters},
  year={2017},
  volume={188},
  pages={108-115}
}
Myeloid-derived suppressor cells (MDSCs) are key regulators of adaptive immunity by suppressing T-cell functions. However, their potential action on or interaction with B cells remained poorly understood. Here we demonstrate that human polymorphonuclear MDSCs differentially modulate B-cell function by suppressing B-cell proliferation and antibody production. We further demonstrate that this MDSC-mediated effect is cell contact dependent and involves established mediators such as arginase-1… CONTINUE READING
3 Citations
51 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 51 references

I

  • M. Ballbach, T. Hall, A. Brand, D. Neri, A. Singh
  • Schaefer, et al., Induction of myeloid-Derived…
  • 2017

C

  • M. Bodogai, K. Moritoh
  • Lee-Chang, C.M. Hollander, C.A. Sherman-Baust, R…
  • 2015
1 Excerpt

Similar Papers

Loading similar papers…