Myeloid-derived suppressor cells modulate B-cell responses.

  title={Myeloid-derived suppressor cells modulate B-cell responses.},
  author={Felipe Lelis and Jennifer Jaufmann and Anurag Singh and Katja Fromm and Annkathrin Chiara Teschner and Simone P{\"o}schel and Iris Schaefer and Sandra Beer-Hammer and Nikolaus Rieber and Dominik Hartl},
  journal={Immunology letters},
Myeloid-derived suppressor cells (MDSCs) are key regulators of adaptive immunity by suppressing T-cell functions. However, their potential action on or interaction with B cells remained poorly understood. Here we demonstrate that human polymorphonuclear MDSCs differentially modulate B-cell function by suppressing B-cell proliferation and antibody production. We further demonstrate that this MDSC-mediated effect is cell contact dependent and involves established mediators such as arginase-1… CONTINUE READING
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