Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor.

@article{Hoechst2009MyeloidDS,
  title={Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor.},
  author={Bastian Hoechst and Torsten Voigtlaender and Lars A. Ormandy and Jaba Gamrekelashvili and Fei Zhao and Heiner Wedemeyer and Frank Lehner and Michael P. Manns and Tim F Greten and Firouzeh Korangy},
  journal={Hepatology},
  year={2009},
  volume={50 3},
  pages={799-807}
}
UNLABELLED Several immune suppressive mechanisms that evade the host immune response have been described in patients with hepatocellular carcinoma (HCC); one of these mechanisms is expansion of myeloid-derived suppressor cells (MDSCs). MDSCs have been shown to inhibit T cell responses in tumor-bearing mice, but little is known about these cells in humans. Here, we have analyzed and characterized the effect of MDSCs on the innate immune system, in particular, their interaction with natural… CONTINUE READING

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