Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer.

@article{Sawant2013MyeloidderivedSC,
  title={Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer.},
  author={Anandi B Sawant and Jessy S Deshane and Joel Jules and Carnella M Lee and Brittney A. Harris and Xu Feng and Selvarangan Ponnazhagan},
  journal={Cancer research},
  year={2013},
  volume={73 2},
  pages={672-82}
}
Enhanced bone destruction is a hallmark of various carcinomas such as breast cancer, where osteolytic bone metastasis is associated with increased morbidity and mortality. Immune cells contribute to osteolysis in cancer growth, but the factors contributing to aggressive bone destruction are not well understood. In this study, we show the importance of myeloid-derived suppressor cells (MDSC) in this process at bone metastatic sites. Because MDSC originate from the same myeloid lineage as… CONTINUE READING
45 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Safety and efficacy of gemcitabine plus cisplatin combination in pretreated metastatic breast cancer patients

  • LG Brito, JM de Andrade, T Lins-Almeida, FE Zola, MN Pinheiro, HR Marana
  • Med Oncol 2012;29:33–8
  • 2012

Elevated levels of NO are localized to distal airways in asthma

  • JT Anderson, ZengM, Q Li, R Stapley, DR 2ndMoore, B Chenna
  • Free Radic Biol Med
  • 2011
2 Excerpts

Similar Papers

Loading similar papers…