Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy

@article{Baniyash2016MyeloidderivedSC,
  title={Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy},
  author={Michal Baniyash},
  journal={Cancer Immunology, Immunotherapy},
  year={2016},
  volume={65},
  pages={857-867}
}
Chronic inflammation, typical of various diseases including cancer, is a “silent bomb within the body,” leading to complications that are only evident in most cases upon their appearance, when disease is already deteriorated. Chronic inflammation is associated with accumulation of myeloid-derived suppressor cells (MDSCs), which lead to immunosuppression. MDSCs have numerous harmful effects as they support tumor initiation, tumor growth and spreading, which in turn, perpetuate the inflammatory… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Suppressed T-cell receptor zeta chain expression and cytokine production in pancreatic cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2001
View 11 Excerpts
Highly Influenced

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2015
View 2 Excerpts

Pembrolizumab versus Ipilimumab in Advanced Melanoma.

The New England journal of medicine • 2015
View 1 Excerpt

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