Myeloid-derived suppressor cells and their role in CTLA-4 blockade therapy

@article{Coaa2014MyeloidderivedSC,
  title={Myeloid-derived suppressor cells and their role in CTLA-4 blockade therapy},
  author={Yago Pico de Coa{\~n}a and G. Masucci and J. Hansson and R. Kiessling},
  journal={Cancer Immunology, Immunotherapy},
  year={2014},
  volume={63},
  pages={977-983}
}
  • Yago Pico de Coaña, G. Masucci, +1 author R. Kiessling
  • Published 2014
  • Medicine
  • Cancer Immunology, Immunotherapy
  • Abstract Immune checkpoints are a series of inhibitory pathways that are crucial for modulating the intensity and duration of immune response. Among these checkpoints, cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) has been shown to be a key regulator of the early activation of naïve and memory T cells. Immune checkpoint blockade is emerging as one of the most promising therapeutic approaches directed toward the activation of the immune response against tumors. The first of these… CONTINUE READING

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