Myeloid-derived suppressor cells and their role in CTLA-4 blockade therapy

  title={Myeloid-derived suppressor cells and their role in CTLA-4 blockade therapy},
  author={Yago Pico de Coa{\~n}a and Giuseppe V Masucci and Johan Hansson and Rolf Kiessling},
  journal={Cancer Immunology, Immunotherapy},
Immune checkpoints are a series of inhibitory pathways that are crucial for modulating the intensity and duration of immune response. Among these checkpoints, cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) has been shown to be a key regulator of the early activation of naïve and memory T cells. Immune checkpoint blockade is emerging as one of the most promising therapeutic approaches directed toward the activation of the immune response against tumors. The first of these therapies that… CONTINUE READING

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