Myeloid-derived suppressor cells: a novel therapeutic target.

  title={Myeloid-derived suppressor cells: a novel therapeutic target.},
  author={Jennifer S Ko and Ronald M. Bukowski and James H Fincke},
  journal={Current oncology reports},
  volume={11 2},
Immunotherapy and angiogenic inhibitors, used alone or in combination with chemotherapy, represent two promising cancer treatment programs. Each is limited by myeloid-derived suppressor cells (MDSCs), which accumulate in tumor-bearing hosts. MDSCs inhibit effector T-cell function and thus prevent the formation and execution of an effective antitumor immune response. Recently reported studies have shown that MDSCs also function to promote tumor-dependent angiogenesis as well as tumor metastasis… CONTINUE READING


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