Myeloid-derived suppressor cell heterogeneity in human cancers.

  title={Myeloid-derived suppressor cell heterogeneity in human cancers.},
  author={S Solito and Ilaria Marigo and Laura Pinton and Vera Damuzzo and Susanna Mandruzzato and Vincenzo Bronte},
  journal={Annals of the New York Academy of Sciences},
The dynamic interplay between cancer and host immune system often affects the process of myelopoiesis. As a consequence, tumor-derived factors sustain the accumulation and functional differentiation of myeloid cells, including myeloid-derived suppressor cells (MDSCs), which can interfere with T cell-mediated responses. Since both the phenotype and mechanisms of action of MDSCs appear to be tumor-dependent, it is important not only to determine the presence of all MDSC subsets in each cancer… CONTINUE READING
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