Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma.

@article{Raychaudhuri2011MyeloidderivedSC,
  title={Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma.},
  author={Baisakhi Raychaudhuri and Patricia A. Rayman and Joanna A Ireland and Jennifer S Ko and Brian I. Rini and Ernest C. Borden and Jorge Garc{\'i}a and Michael A. Vogelbaum and James Harold Finke},
  journal={Neuro-oncology},
  year={2011},
  volume={13 6},
  pages={
          591-9
        }
}
To assess the accumulation of myeloid-derived suppressor cells (MDSCs) in the peripheral blood of patients with glioma and to define their heterogeneity and their immunosuppressive function. Peripheral blood mononuclear cells (PBMCs) from healthy control subjects and from patients with newly diagnosed glioma were stimulated with anti-CD3/anti-CD28 and T cells assessed for intracellular expression of interferon (IFN)-γ. Antibody staining of PBMCs from glioma patients and healthy donors (CD33… CONTINUE READING
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