Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.

@article{Sriram2012MyeloidDC,
  title={Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.},
  author={Uma Sriram and Linda A Varghese and Heather L. Bennett and Neelakshi R. Jog and Debra K. Shivers and Yue Ning and Edward M Behrens and Roberto Caricchio and Stefania Gallucci},
  journal={Journal of immunology},
  year={2012},
  volume={189 1},
  pages={80-91}
}
Patients with systemic lupus erythematosus show an overexpression of type I IFN-responsive genes that is referred to as "IFN signature." We found that B6.NZMSle1/Sle2/Sle3 (Sle1,2,3) lupus-prone mice also express an IFN signature compared with non-autoimmune C57BL/6 mice. In vitro, myeloid dendritic cells (mDCs) (GM-CSF bone marrow-derived dendritic cells; BMDCs) from Sle1,2,3 mice constitutively overexpressed IFN-responsive genes such as IFN-β, Oas-3, Mx-1, ISG-15, and CXCL10 and members of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
14 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…