Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer.

@article{Lee2015MyeloidCL,
  title={Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer.},
  author={Wan-Sik Lee and Young-Lan Park and Nuri Kim and Hyung-Hoon Oh and Dong-Jun Son and Miyoung Kim and Chan Young Oak and Cho-Yun Chung and Hyung-Chul Park and Jong-sun Kim and Dae Seong Myung and Sung-Bum Cho and Young-Eun Joo},
  journal={International journal of oncology},
  year={2015},
  volume={46 5},
  pages={
          2154-62
        }
}
The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognostic value of its expression in gastric cancer. PcDNA3.1-Mcl-1 expression and Mcl-1 siRNA vectors were used to overexpress and silence Mcl-1 expression in gastric cancer cell lines… 
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Results Citations
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26 Citations

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Citation Type

Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer
TLDR
MCL-1 may serve as a potential prognostic biomarker and a novel therapeutic target in NSCLC and is correlated inversely with AI and positively with Ki-67 index.
Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer
TLDR
Elevated expression of Mcl-1 might be inversely proportional to disease progression of NSCLC patients by promoting cell proliferation and inhibiting apoptosis, and Mcl -1 might serve as novel biomarker of poor prognosis for NSclC patients.
MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway
TLDR
Investigation of the ability of MCL1 silencing to influence glioma cell senescence and apoptosis through the mediation of the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt) signaling pathway suggested that decreasing the expression of M CL1 might have therapeutic functions in gliomas.
Myeloid cell leukemia-1 is an important predictor of survival and progression of small cell lung cancer.
TLDR
Mcl-1 expression level was demonstrated to be a prognostic biomarker for survival outcomes and cancer progression in the patients with SCLC and could be used as a valuable biomarker in identifying those patients with high risk of treatment failure.
Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis
TLDR
The current study suggests that MCL-1 contributes to the development of ESCC and is a promising therapeutic target for chemosensitization of ES CC cells to cisplatin.
Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer
TLDR
Findings suggest that Genipin contributes to the collapse of mitochondrial functions like MMP, which is closely related to mitochondrial function, in gastric cancer.
The regulatory role of Mcl-1 in apoptosis of mouse peritoneal macrophage infected with M. tuberculosis strains that differ in virulence.
TLDR
M cl-1-shRNA intervention effectively down-regulated Mcl-1 expression, significantly increased host macrophage apoptosis, and induced cytochrome-c expression in mouse peritoneal macrophages infected withMTB strains of different virulence, and these changes were influenced by the virulence of the MTB strains.
Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
TLDR
This work studied the expression of emerging prognostic markers SOX9, MCL-1, and SPOCK1 in a cohort of gastric cancer by immunohistochemistry and investigated how individual biomarkers and their combinations predict disease prognosis.
miR-509-3p promotes cisplatin-induced apoptosis in ovarian cancer cells through the regulation of anti-apoptotic genes.
TLDR
It is demonstrated that miR-509-3p could sensitize ovarian cancer cells to cisplatin treatment by targeting multiple anti-apoptosis genes including BCL2.
LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation
TLDR
This study suggested that LINC00152 was overexpressed in GC tissues, and it down-regulated miR-193a-3p to enhance MCL1 expression thereby promoting GC cells proliferation.
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