Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice.

@article{Lalani2015MyeloidCT,
  title={Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice.},
  author={Almin I. Lalani and Carissa R. Moore and Chang Luo and Benjamin Z Kreider and Yan Liu and Herbert C. Morse and Ping Xie},
  journal={Journal of immunology},
  year={2015},
  volume={194 1},
  pages={334-48}
}
Myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells, are crucial players in innate immunity and inflammation. These cells constitutively or inducibly express a number of receptors of the TNFR and TLR families, whose signals are transduced by TNFR-associated factor (TRAF) molecules. In vitro studies showed that TRAF3 is required for TLR-induced type I IFN production, but the in vivo function of TRAF3 in myeloid cells remains unknown. In this article, we report the… CONTINUE READING
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