Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

  title={Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer},
  author={Minu K. Srivastava and Li Zhu and Marni E. Harris-White and Upendra K. Kar and Min Huang and Ming F. Johnson and Jay Moon Lee and David Elashoff and Robert M. Strieter and Steven Dubinett and Sherven P Sharma},
  booktitle={PloS one},
BACKGROUND Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer. PRINCIPAL FINDINGS Individual antibody mediated depletion of MDSC (anti-Gr1 or anti-Ly6G) enhanced the antitumor activity against lung cancer. In comparison to controls, MDSC depletion enhanced the APC activity and… CONTINUE READING
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