Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

@inproceedings{Srivastava2012MyeloidSC,
  title={Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer},
  author={Minu K. Srivastava and Li Zhu and Marni E. Harris-White and Upendra K. Kar and Min Huang and Ming F. Johnson and Jay Moon Lee and David Elashoff and Robert M. Strieter and Steven Dubinett and Sherven P Sharma},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer. PRINCIPAL FINDINGS Individual antibody mediated depletion of MDSC (anti-Gr1 or anti-Ly6G) enhanced the antitumor activity against lung cancer. In comparison to controls, MDSC depletion enhanced the APC activity and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
81 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Polarization of tumorassociated neutrophil phenotype by TGF - beta : ‘ ‘ N 1 ’ ’ versus ‘ ‘ N 2 ’ ’ TAN

  • ZG Fridlender, J Sun, S Kim, V Kapoor, G Cheng
  • Cancer Cell
  • 2009

Similar Papers

Loading similar papers…