Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet–Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype

@article{Lee2017MyeloidS6,
  title={Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet–Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype},
  author={Youngyi Lee and Sun‐O Ka and Hye-Na Cha and Yu Na Chae and Mi-kyung Kim and So-Young Park and Eun Ju Bae and Byung-Hyun Park},
  journal={Diabetes},
  year={2017},
  volume={66},
  pages={2659 - 2668}
}
Obesity-related insulin resistance is closely associated with macrophage accumulation and subsequent cytokine release in local tissues. Sirtuin 6 (Sirt6) is known to exert an anti-inflammatory function, but its role in macrophages in the context of obesity has not been investigated. We generated myeloid-specific Sirt6 knockout (mS6KO) mice and investigated the metabolic characteristics after high-fat diet (HFD) feeding for 16 weeks. Compared with their wild-type littermates, HFD-fed mS6KO mice… 
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