Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis

@article{Fujii2013MyeloidDerivedSC,
  title={Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis},
  author={Wataru Fujii and Eishi Ashihara and Hideyo Hirai and Hidetake Nagahara and Naoko Kajitani and Kazuki Fujioka and Ken Murakami and Takahiro Seno and Aihiro Yamamoto and Hidetaka Ishino and Masataka Kohno and Taira Maekawa and Yutaka Kawahito},
  journal={The Journal of Immunology},
  year={2013},
  volume={191},
  pages={1073 - 1081}
}
Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell responses. The role of MDSCs in autoimmune diseases remains controversial, and little is known about the function of MDSCs in autoimmune arthritis. In this study, we clarify that MDSCs play crucial roles in the regulation of proinflammatory immune response in a collagen-induced arthritis (CIA) mouse model. MDSCs accumulated in the spleens of mice with CIA when arthritis severity peaked. These MDSCs… 

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TLDR
The potential of MDSC-based cell therapy for the treatment of autoimmune diseases is described and some of hurdles facing the implementation of this therapy are noted.
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TLDR
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Suppression of Proteoglycan-Induced Autoimmune Arthritis by Myeloid-Derived Suppressor Cells Generated In Vitro from Murine Bone Marrow
TLDR
Injection of BM-MDSCs into mice with PGIA ameliorated arthritis and reduced PG-specific T-cell responses and serum antibody levels, and enrichment of BM in MDSCs could improve the therapeutic efficacy of BM transplantation in RA.
Myeloid‐Derived Suppressor Cells
TLDR
The role of MDSCs in regulation of immune responses in both health and disease makes them an attractive therapeutic target in conquering various human diseases and they are expanded in cancer and other pathological conditions owing to abnormal myelopoiesis.
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