Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis

@article{Fujii2013MyeloidDerivedSC,
  title={Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis},
  author={W. Fujii and E. Ashihara and H. Hirai and H. Nagahara and N. Kajitani and Kazuki Fujioka and K. Murakami and T. Seno and A. Yamamoto and H. Ishino and M. Kohno and T. Maekawa and Y. Kawahito},
  journal={The Journal of Immunology},
  year={2013},
  volume={191},
  pages={1073 - 1081}
}
Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell responses. The role of MDSCs in autoimmune diseases remains controversial, and little is known about the function of MDSCs in autoimmune arthritis. In this study, we clarify that MDSCs play crucial roles in the regulation of proinflammatory immune response in a collagen-induced arthritis (CIA) mouse model. MDSCs accumulated in the spleens of mice with CIA when arthritis severity peaked. These MDSCs… Expand
The Immunoregulatory Role of Myeloid-Derived Suppressor Cells in the Pathogenesis of Rheumatoid Arthritis
Role of myeloid-derived suppressor cells in autoimmune disease.
Myeloid‐derived suppressor cells regulate T cell and B cell responses during autoimmune disease
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