Myeloid Cells Contribute to Tumor Lymphangiogenesis

  title={Myeloid Cells Contribute to Tumor Lymphangiogenesis},
  author={Adrian Zumsteg and Vanessa Baeriswyl and Natsuko Imaizumi and Reto Albert Schwendener and Curzio R{\"u}egg and Gerhard Christofori},
  booktitle={PloS one},
The formation of new blood vessels (angiogenesis) and lymphatic vessels (lymphangiogenesis) promotes tumor outgrowth and metastasis. Previously, it has been demonstrated that bone marrow-derived cells (BMDC) can contribute to tumor angiogenesis. However, the role of BMDC in lymphangiogenesis has largely remained elusive. Here, we demonstrate by bone marrow transplantation/reconstitution and genetic lineage-tracing experiments that BMDC integrate into tumor-associated lymphatic vessels in the… CONTINUE READING


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