Myeloglycan, a series of E-selectin-binding polylactosaminolipids found in normal human leukocytes and myelocytic leukemia HL60 cells.

@article{Stroud1995MyeloglycanAS,
  title={Myeloglycan, a series of E-selectin-binding polylactosaminolipids found in normal human leukocytes and myelocytic leukemia HL60 cells.},
  author={Mark R. Stroud and Kazuko Handa and Ken-ichi Ito and Mary Ellen Salyan and H. Y. Fang and Steven B. Levery and S I Hakamori and Bruce B. Reinhold and Vernon N. Reinhold},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={209 3},
  pages={777-87}
}
Sialosyl-Lex (SLex) is assumed to be the binding epitope of E- and P-selectin in normal human neutrophils and myelocytic leukemia HL60 cells. Glycosphingolipid (GSL) fractions from large quantities of normal human neutrophils and HL60 cell extract did not contain SLex GSLs having 6-10 sugar residues, as commonly found in solid tumor cells and tissues. Instead, the binding target of E-selectin was revealed to be a series of long-chain, unbranched polylactosamine GSLs with terminally sialylated… CONTINUE READING