Myelofibrosis in primary myelodysplastic syndromes: a retrospective study of 352 patients.

@article{Maschek1992MyelofibrosisIP,
  title={Myelofibrosis in primary myelodysplastic syndromes: a retrospective study of 352 patients.},
  author={Hansj{\"o}rg Maschek and Axel Georgii and Vassiliki D Kaloutsi and Martin Werner and K Bandecar and Michael Kressel and Harald Choritz and Mathias Freund and D Hufnagl},
  journal={European journal of haematology},
  year={1992},
  volume={48 4},
  pages={208-14}
}
In a retrospective study of 352 patients with primary myelodysplastic syndromes, 61 (17.3%) revealed myelofibrosis in bone marrow biopsies. The fibrosis was observed to occur mostly focally (41/61 cases), and collagen deposits were found very rarely (4/61). The histopathology of bone marrow biopsies revealed hyperplasia and disturbed differentiation in megakaryopoiesis; the frequency and grade of dysplasia in megakaryopoiesis increased with advancing myelofibrosis. Reticulin fibrosis occurred… CONTINUE READING
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