Myelofibrosis and systemic lupus erythematosus: reversal of fibrosis with high-dose corticosteroid therapy.

@article{Inoue1992MyelofibrosisAS,
  title={Myelofibrosis and systemic lupus erythematosus: reversal of fibrosis with high-dose corticosteroid therapy.},
  author={Yuriko Inoue and Atsushi Matsubara and Shigeru Okuya and Kazuhiro Okafuji and Kohei Kaku and Tomoki Kaneko},
  journal={Acta haematologica},
  year={1992},
  volume={88 1},
  pages={32-6}
}
A case of myelofibrosis in association with systemic lupus erythematosus (SLE) is reported. Acute thrombocytopenia and a bleeding tendency developed in a 24-year-old woman with SLE. Bone marrow aspiration was unsuccessful due to myelofibrosis. Pulse therapy with methylprednisolone reversed both thrombocytopenia and myelofibrosis. A review of the literature revealed that the coexistence of SLE and myelofibrosis is a rare occurrence. Only 7 cases, to our knowledge, have ever been reported in… CONTINUE READING