Myelodysplastic syndromes associated with interstitial deletion of chromosome 5q: clinicopathologic correlations and new insights from the pre-lenalidomide era.

@article{Holtan2008MyelodysplasticSA,
  title={Myelodysplastic syndromes associated with interstitial deletion of chromosome 5q: clinicopathologic correlations and new insights from the pre-lenalidomide era.},
  author={Shernan Grace Holtan and Rafael Santana-Davila and Gordon W. Dewald and Rhett P Khetterling and Ryan A. Knudson and James D. Hoyer and Dong Chen and Curtis A. Hanson and Luis F Porrata and Ayalew Tefferi and David P Steensma},
  journal={American journal of hematology},
  year={2008},
  volume={83 9},
  pages={708-13}
}
To better estimate prognosis for patients with myelodysplastic syndromes (MDS) associated with clonal interstitial deletions of the long arm of chromosome 5 (del(5q)), we reviewed the medical records of 130 adults with del(5q) MDS seen at our institution over a 15-year period. Overall median survival of this cohort was 9.5 months, shorter than reported in earlier series. The least favorable outcomes are associated with complex cytogenetics, lack of any normal metaphases, normocytic rather than… CONTINUE READING

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