Myelodysplastic syndrome and aplastic anemia: distinct entities or diseases linked by a common pathophysiology?

@article{Barrett2000MyelodysplasticSA,
  title={Myelodysplastic syndrome and aplastic anemia: distinct entities or diseases linked by a common pathophysiology?},
  author={John A Barrett and Yogen Saunthararajah and Jeff Molldrem},
  journal={Seminars in hematology},
  year={2000},
  volume={37 1},
  pages={15-29}
}
It is often difficult to distinguish myelodysplastic syndrome (MDS) from severe aplastic anemia (SAA) because both can present with profoundly hypocellular bone marrows. The distinction matters because although both conditions are complicated by pancytopenia, the risk of progression to acute leukemia is much greater in MDS. This chapter reexamines the relationship between SAA and MDS. The clinical and morphological features and pathophysiology of AA (including moderate and severe forms of… CONTINUE READING

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