Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.

@article{Nguyen2011MyelinationTZ,
  title={Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.},
  author={Judy V Nguyen and Ileana Soto and K. Kim and Eric A Bushong and Ericka N. Oglesby and Francisco Javier Valiente-Soriano and Zhiyong Yang and Chung-ha O. Davis and Joseph L. Bedont and Janice L Son and John O Wei and Vladimir L Buchman and Donald J. Zack and Manuel Vidal-Sanz and Mark H. Ellisman and Nicholas Marsh-Armstrong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 3},
  pages={1176-81}
}
Optic nerve head (ONH) astrocytes have been proposed to play both protective and deleterious roles in glaucoma. We now show that, within the postlaminar ONH myelination transition zone (MTZ), there are astrocytes that normally express Mac-2 (also known as Lgals3 or galectin-3), a gene typically expressed only in phagocytic cells. Surprisingly, even in healthy mice, MTZ and other ONH astrocytes constitutive internalize large axonal evulsions that contain whole organelles. In mouse glaucoma… CONTINUE READING
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