Myelination arrest demonstrated using magnetic resonance imaging in a child with type I GM1 gangliosidosis.

@article{Shen1998MyelinationAD,
  title={Myelination arrest demonstrated using magnetic resonance imaging in a child with type I GM1 gangliosidosis.},
  author={Wan-Chieh Shen and Fuu Jen Tsai and Chang Hai Tsai},
  journal={Journal of the Formosan Medical Association = Taiwan yi zhi},
  year={1998},
  volume={97 4},
  pages={296-9}
}
An 18-month-old girl was diagnosed as having GM1 gangliosidosis, on the basis of the clinical symptoms of muscle stiffness, developmental retardation, hepatosplenomegaly, and kyphoscoliosis and a laboratory study that revealed a deficiency in the lysosomal degradative enzyme beta-galactosidase. Magnetic resonance T1-weighted images showed persistent hyperintensity in the bilateral thalami, brainstem, and deep cerebellum at 14 and 18 months of age, indicating arrest of the myelination process in… CONTINUE READING