Myelin water imaging of multiple sclerosis at 7 T: Correlations with histopathology

@article{Laule2008MyelinWI,
  title={Myelin water imaging of multiple sclerosis at 7 T: Correlations with histopathology},
  author={Cornelia Laule and Piotr Kozlowski and Esther Leung and David K.B. Li and Alex L. MacKay and G. R. Wayne Moore},
  journal={NeuroImage},
  year={2008},
  volume={40},
  pages={1575-1580}
}
Myelin water imaging (MWI) promises to be invaluable in understanding neurological diseases like MS. However, a limitation of MWI is signal to noise ratio. Recently, a number of investigators have performed MWI at field strengths higher than 1.5 T. Our goal was to determine if myelin water imaging at increased SNR, arising from the use of a small bore 7 T MR system with optimized coil geometry, enables the production of superior myelin water maps with increased spatial detail and enables better… 
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Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis
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Comparing the methods in terms of their statistical sensitivity to MS lesions in WM, MWF‐D demonstrated the best accuracy, and to aid future power analysis, the average and standard deviation volumes of the four techniques are provided.
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TLDR
The correlation ofMyelin water imaging, an MR measure of myelin content, with quantitative histopathologic measures of myelination density is determined and a strong correlation with myelin stain is found, validating MWF as a measure of the myelin density.
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TLDR
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