Myelin under stress.

@article{DAntonio2009MyelinUS,
  title={Myelin under stress.},
  author={Maurizio D'Antonio and Maria Laura Feltri and Lawrence Wrabetz},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 15},
  pages={
          3241-9
        }
}
The capacity to fold proteins properly is fundamental for cell survival. Secreted and transmembrane proteins are synthesized in the endoplasmic reticulum (ER), an organelle that has the ability to discriminate between native and nonnative proteins, in a process called protein quality control. When folding is not properly achieved, misfolded proteins can accumulate. The terminally misfolded proteins are typically retrotranslocated into the cytoplasm for degradation by the proteasome, in a… CONTINUE READING
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