Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

@inproceedings{Hughes2018MyelinRT,
  title={Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex},
  author={Ethan G Hughes and Jennifer L Orthmann-Murphy and Abraham J Langseth and Dwight E Bergles},
  booktitle={Nature Neuroscience},
  year={2018}
}
Oligodendrocyte generation in the adult CNS provides a means to adapt the properties of circuits to changes in life experience. However, little is known about the dynamics of oligodendrocytes and the extent of myelin remodeling in the mature brain. Using longitudinal in vivo two-photon imaging of oligodendrocytes and their progenitors in the mouse cerebral cortex, we show that myelination is an inefficient and extended process, with half of the final complement of oligodendrocytes generated… CONTINUE READING

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