Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice.

@article{Bettelli2006MyelinOG,
  title={Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice.},
  author={Estelle Bettelli and D. Baeten and Anneli J{\"a}ger and Raymond A Sobel and Vijay K Kuchroo},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 9},
  pages={2393-402}
}
Multiple sclerosis (MS) is a clinically and pathologically heterogeneous inflammatory/demyelinating disease of the CNS. In the MS variant Devic disease, lesions are predominantly found in the optic nerves and spinal cord but not the brain. The immunological bases of the different forms of MS are unknown. We previously generated myelin oligodendrocyte glycoprotein-specific (MOG-specific) TCR transgenic mice (TCRMOG mice; also referred to as 2D2 mice) and reported that a large proportion of these… CONTINUE READING
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