Myelin basic protein in the cerebrospinal fluid of patients infected with HIV

@article{Pfister2004MyelinBP,
  title={Myelin basic protein in the cerebrospinal fluid of patients infected with HIV},
  author={Hans-walter Pfister and Karl Max Einh{\"a}upl and Manfred Wick and Ahmad Fateh-Moghadam and Marion Huber and Eva Schielke and Frank D. Goebel and Andreas Matuschke and B. Heinrich and J R Bogner and Monika Fr{\"o}schl and W. Pf{\"a}ffl and Manfred Ackenheil},
  journal={Journal of Neurology},
  year={2004},
  volume={236},
  pages={288-291}
}
SummaryThe major pathological abnormalities of HIV encephalopathy are infiltrates of macrophages, multinucleated giant cells, microglial nodules and demyelination. Elevated myelin basic protein (MBP) levels in the cerebrospinal fluid (CSF) provide a marker for central nervous system demyelination. The purpose of this study was to investigate the possible role of CSF MBP as a useful and early marker for HIV encephalopathy. The CSF of 40 consecutive patients with HIV infection of various clinical… 
Cerebrospinal fluid (CSF) analyses in HIV-1 primary neurological disease
TLDR
This paper will focus on CSF findings in HIV-1 Neurological Disease (ND), exploring the papers that utilize CSF variables as dependent measures to explore the effects of HIV disease, particularly HIV ND, cited in Index Medicus and MEDLINE data base and published in Spanish, Italian and English between 1985 to 1991.
Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization—case study
TLDR
The CSF biomarker analysis in this patient showed that symptomatic CSF escape is accompanied by CNS inflammation, high levels of cell and humoral immune biomarkers, CNS barrier dysfunction, and an increase in neuronal injury biomarkers with demyelization.
Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease
TLDR
This work reviews known myelin IDPs, their conservation, molecular characteristics and functions, and their disease relevance, along with open questions and speculations, placing emphasis on classifying the molecular details of IDPs in myelin.

References

SHOWING 1-10 OF 66 REFERENCES
Myelin basic protein in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases
TLDR
The presence of material cross-reactive with BP fragment 89–169 is not specific for multiple sclerosis, but is a useful parameter in diagnosis and evaluation of MS.
Myelin basic protein in CSF and blood. Relationship between its presence and the occurrence of a destructive process in the brains of encephalitic patients.
Serum and CSF levels of myelin basic protein (MBP) were measured in 50 patients with encephalitis of various origins and severity. In nearly 50%, the CSF samples were found to display
Cerebrospinal myelin basic protein in multiple sclerosis. Identification of two groups of patients with acute exacerbation.
The myelin basic protein concentration in the cerebrospinal fluid (CSF) of 125 patients with multiple sclerosis was measured using a radioimmunoassay technique with a detection level of 200 pg/mL and
Chronic HIV encephalitis — I. cerebrospinal fluid diagnosis
TLDR
Findings indicate an early and frequent invasion of the CNS in HIV infection, which was found in 47% of the patients in stage I, 67% in stages II, and 84% in stage III.
Review of central nervous system pathology in human immunodeficiency virus infection
  • C. Petito
  • Medicine, Biology
    Annals of neurology
  • 1988
TLDR
The incidence of vacuolar myelopathy is increased in patients with HIV encephalitis, its etiology is not yet established, and the severity of the pathological lesions correlates not only with symptoms and signs of spinal cord disease but also with dementia.
Immunoreactive myelin basic protein in the cerebrospinal fluid in neurological disorders
TLDR
The presence in CSF of material cross‐reactive with BP peptide 43‐88 does not have diagnostic specificit for MS but can be used as a means for determining recent myelin injury.
A diagnostic index of active demyelination: Myelin basic protein in cerebrospinal fluid
TLDR
A radioimmunoassay to measure a specific neurological component, the basic protein of myelin, and has used this test for assessing this component in spinal fluid, which is a useful adjunct in the diagnosis of multiple sclerosis and evaluation of potential therapy.
Neuropathology of Acquired Immunodeficiency Syndrome (AIDS): An Autopsy Review
TLDR
This survey shows that neuropathologic complications of AIDS are frequent and Infections are the most common complication and are caused by probable LAV/HTLV-III infection, or by opportunistic organisms.
Subacute encephalomyelitis of AIDS and its relation to HTLV‐III infection
TLDR
It is concluded that subacute encephalitis is common in AIDS patients and is most likely caused by CNS infection with HTLV-III.
CSF antibodies to myelin basic protein and to myelin‐associated glycoprotein in multiple sclerosis. Evidence of the intrathecal production of antibodies
TLDR
Indirect data were obtained that autoantibodies whose antigens are associated with myelinoligodendrocyte unit are produced locally within the central nervous system (CNS) and indicates an active humoral autoimmune process in which more than one autoantigen is involved.
...
1
2
3
4
5
...