Myelin basic protein in the cerebrospinal fluid of patients infected with HIV

  title={Myelin basic protein in the cerebrospinal fluid of patients infected with HIV},
  author={Hans-walter Pfister and Karl Max Einh{\"a}upl and Manfred Wick and Ahmad Fateh-Moghadam and Marion Huber and Eva Schielke and Frank D. Goebel and Andreas Matuschke and B. Heinrich and J R Bogner and Monika Fr{\"o}schl and W. Pf{\"a}ffl and Manfred Ackenheil},
  journal={Journal of Neurology},
SummaryThe major pathological abnormalities of HIV encephalopathy are infiltrates of macrophages, multinucleated giant cells, microglial nodules and demyelination. Elevated myelin basic protein (MBP) levels in the cerebrospinal fluid (CSF) provide a marker for central nervous system demyelination. The purpose of this study was to investigate the possible role of CSF MBP as a useful and early marker for HIV encephalopathy. The CSF of 40 consecutive patients with HIV infection of various clinical… 
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Review of central nervous system pathology in human immunodeficiency virus infection
  • C. Petito
  • Medicine, Biology
    Annals of neurology
  • 1988
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